In Vivo Investigation of (2-Hydroxypropyl)-β-cyclodextrin-Based Formulation of Spironolactone in Aqueous Solution for Paediatric Use

Spironolactone (SPL), a potent anti-aldosterone steroidal drug used to treat several diseases in paediatric patients (e.g., hypertension, primary aldosteronism, Bartter’s syndrome, and congestive heart failure), is not available in child-friendly dosage forms, and spironolactone liquids have been re...

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Detalhes bibliográficos
Main Authors: Antonio Lopalco, Annachiara Manni, Alexander Keeley, Shozeb Haider, Wenliang Li, Angela Lopedota, Cosimo Damiano Altomare, Nunzio Denora, Catherine Tuleu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Pharmaceutics
Assuntos:
spironolactone
hydroxypropyl-β-cyclodextrin
palatability
cyclodextrin inclusion
phase solubility study
brief-access taste aversion
Acesso em linha:https://www.mdpi.com/1999-4923/14/4/780
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