Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach

Carbonic anhydrases (CAs) are ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton. In humans there are 15 isoforms among which only 12 are catalytically active. Since active human (h) CAs show different efficiency, the understanding of the mo...

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Detalhes bibliográficos
Main Authors: Giuseppina De Simone, Anna Di Fiore, Emanuela Truppo, Emma Langella, Daniela Vullo, Claudiu T. Supuran, Simona Maria Monti
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2019-01-01
Colecção:Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:
cytosolic human carbonic anhydrases
catalytic activity
proton transfer
histidine cluster
site-specific mutagenesis
Acesso em linha:http://dx.doi.org/10.1080/14756366.2019.1653290
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