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TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model.

The renin-angiotensin system (RAS), which plays an important role in the progression of heart failure, is efficiently blocked by the inhibition of renin, the rate-limiting enzyme in the RAS cascade. In the present study, we investigated the cardioprotective effects of TAK-272 (SCO-272, imarikiren),...

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Bibliografski detalji
Glavni autori: Tomoya Hara, Satoshi Nishimura, Toshihiro Yamamoto, Yumiko Kajimoto, Keiji Kusumoto, Ray Kanagawa, Shota Ikeda, Tomoyuki Nishimoto
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2018-01-01
Serija:PLoS ONE
Online pristup:http://europepmc.org/articles/PMC6084973?pdf=render
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