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A network of multi-tasking proteins at the DNA replication fork preserves genome stability.

To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately 4,700 viable yeast deletion mutants and determined the fitness of the double mutants. Fifty-six DNA2-...

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書誌詳細
主要な著者: Martin E Budd, Amy Hin Yan Tong, Piotr Polaczek, Xiao Peng, Charles Boone, Judith L Campbell
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2005-12-01
シリーズ:PLoS Genetics
オンライン・アクセス:http://europepmc.org/articles/PMC1298934?pdf=render
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