A network of multi-tasking proteins at the DNA replication fork preserves genome stability.

To elucidate the network that maintains high fidelity genome replication, we have introduced two conditional mutant alleles of DNA2, an essential DNA replication gene, into each of the approximately 4,700 viable yeast deletion mutants and determined the fitness of the double mutants. Fifty-six DNA2-...

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Bibliografiske detaljer
Main Authors: Martin E Budd, Amy Hin Yan Tong, Piotr Polaczek, Xiao Peng, Charles Boone, Judith L Campbell
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2005-12-01
Serier:PLoS Genetics
Online adgang:http://europepmc.org/articles/PMC1298934?pdf=render
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