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ARID3a expression in human hematopoietic stem cells is associated with distinct gene patterns in aged individuals

Abstract Background Immunologic aging leads to immune dysfunction, significantly reducing the quality of life of the elderly. Aged-related defects in early hematopoiesis result in reduced lymphoid cell development, functionally defective mature immune cells, and poor protective responses to vaccines...

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Detalhes bibliográficos
Main Authors: Michelle L. Ratliff, Joshua Garton, Judith A. James, Carol F. Webb
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-09-01
Colecção:Immunity & Ageing
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Acesso em linha:http://link.springer.com/article/10.1186/s12979-020-00198-6
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