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Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma

Background: Hepatoblastoma (HB) is the most common pediatric liver malignancy. Despite advances in chemotherapeutic regimens and surgical techniques, the survival of patients with advanced HB remains poor, underscoring the need for new therapeutic approaches. Chloroquine (CQ), a drug used to treat m...

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Main Authors: Katja Eloranta, Stefano Cairo, Emmi Liljeström, Tea Soini, Antti Kyrönlahti, Jean-Gabriel Judde, David B. Wilson, Markku Heikinheimo, Marjut Pihlajoki
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
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Acceso en liña:https://www.frontiersin.org/article/10.3389/fonc.2020.01138/full
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