MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy

An individual tumor can present intratumoral phenotypic heterogeneity, containing tumor cells with different phenotypes that do not present irreversible genetic alterations. We have developed a mouse cancer model, named GR9, derived from a methylcholanthrene-induced fibrosarcoma that was adapted to...

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Bibliografski detalji
Glavni autori: Irene Romero, Cristina Garrido, Ignacio Algarra, Virginia Chamorro, Antonia Collado, Federico Garrido, Angel M. Garcia-Lora
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018-01-01
Serija:Frontiers in Immunology
Teme:
intratumoral heterogeneity
MHC
metastases
T lymphocytes
immunotherapy
Online pristup:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00102/full
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