Heterologous Synthesis of Monacolin J by Reconstructing Its Biosynthetic Gene Cluster in <i>Aspergillus niger</i>

Monacolin J (MJ), a key precursor of Lovastatin, could synthesize important statin drug simvastatin by hydrolyzing lovastatin and adding different side chains. In this study, to reduce the cumbersome hydrolysis of lovastatin to produce MJ in the native strain <i>Aspergillus terreus</i>,...

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Detalhes bibliográficos
Main Authors: Xu Zeng, Junwei Zheng, Feifei Lu, Li Pan, Bin Wang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Journal of Fungi
Assuntos:
Monacolin J
heterologous synthesis
reconstruction of the biosynthetic gene cluster
CRISPR/Cas9 homology-directed recombination (CRISPR-HDR)
<i>Aspergillus niger</i>
Acesso em linha:https://www.mdpi.com/2309-608X/8/4/407
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