Identification of MicroRNA-Target Gene-Transcription Factor Regulatory Networks in Colorectal Adenoma Using Microarray Expression Data

ObjectiveThe aim of the study was to find the key genes, microRNAs (miRNAs) and transcription factors (TFs) and construct miRNA-target gene-TF regulatory networks to investigate the underlying molecular mechanism in colorectal adenoma (CRA).MethodsFour mRNA expression datasets and one miRNA expressi...

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Main Authors: Yadong Gao, Shenglai Zhang, Yan Zhang, Junbo Qian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-05-01
Colecção:Frontiers in Genetics
Assuntos:
colorectal adenoma
differentially expressed miRNAs
differentially expressed genes
transcription factor
regulatory network
bioinformatic
Acesso em linha:https://www.frontiersin.org/article/10.3389/fgene.2020.00463/full
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