Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies

Tandem single-chain variable fragment (scFv) bispecific antibodies (bsAb) are one of the most promising bsAb formats reported thus far. Yet, because of their increased aggregation propensity, high impurity content due to low expression level, smaller size and lack of the Fc region, it is challenging...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Serene W. Chen, Darryl Tan, Yuan Sheng Yang, Wei Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2020-01-01
Colecção:mAbs
Assuntos:
Bispecific antibody
tandem single-chain variable fragment
purification
affinity chromatography
high molecular weight
L-Arginine monohydrochloride
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2020.1718440
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados