Development of a high-throughput assay to detect antibody inhibition of low pH induced conformational changes of influenza virus hemagglutinin.

Many broadly neutralizing antibodies (bnAbs) bind to conserved areas of the hemagglutinin (HA) stalk region and can inhibit the low pH induced HA conformational changes necessary for viral membrane fusion activity. We developed and evaluated a high-throughput virus-free and cell-free ELISA based low...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jessica F Trost, Elizabeth H LeMasters, Feng Liu, Paul Carney, Xiuhua Lu, Kanetsu Sugawara, Seiji Hongo, James Stevens, David A Steinhauer, Terrence Tumpey, Jacqueline M Katz, Min Z Levine, Zhu-Nan Li
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science (PLoS) 2018-01-01
श्रृंखला:PLoS ONE
ऑनलाइन पहुंच:http://europepmc.org/articles/PMC6021090?pdf=render
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