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Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity

Acetylcholinesterase (AChE) and β-secretase (BACE-1) have become attractive therapeutic targets for Alzheimer’s disease (AD). Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition. In the present work, a series of 14 flavone derivatives was synthesiz...

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Bibliografski detalji
Glavni autori: Thai-Son Tran, Thanh-Dao Tran, The-Huan Tran, Thanh-Tan Mai, Ngoc-Le Nguyen, Khac-Minh Thai, Minh-Tri Le
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-09-01
Serija:Molecules
Teme:
Online pristup:https://www.mdpi.com/1420-3049/25/18/4064
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