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Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats

Abstract Background Estrogen deficiency is thought to be responsible for the higher frequency of aneurysmal subarachnoid hemorrhage in post- than premenopausal women. Estrogen replacement therapy appears to reduce this risk but is associated with significant side effects. We tested our hypothesis th...

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Hlavní autoři: Hidetsugu Maekawa, Yoshiteru Tada, Kenji Yagi, Takeshi Miyamoto, Keiko T. Kitazato, Masaaki Korai, Junichiro Satomi, Tomoki Hashimoto, Shinji Nagahiro
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2017-10-01
Edice:Journal of Neuroinflammation
Témata:
Estrogen
Estrogen receptor
Intracranial aneurysm
Selective estrogen receptor modulator
Subarachnoid hemorrhage
On-line přístup:http://link.springer.com/article/10.1186/s12974-017-0966-7
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