Telomerase-pulsed dendritic cells: preclinical results and outcome of a clinical phase I/II trial in patients with metastatic renal cell carcinoma

Objective: Therapeutic vaccination with dendritic cells (DC) showed promising results in first clinical trials in cases of metastatic renal cell carcinoma (RCC). Human telomerase reverse transcriptase (hTERT) could be a potential target because it is detectable in more than 85% of human tumors inclu...

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Detalhes bibliográficos
Main Authors: Schmiedel, Alexandra, Sommer, Thorsten, Schild, Hans Heinz, Strunk, Holger, von Ruecker, Alexander, Franchy, Christian, Müller, Stefan, Albers, Peter, Sievers, Elisabeth, Märten, Angela, Sauerbruch, Tilman, Schmidt-Wolf, Ingo G.H.
Formato: Artigo
Idioma:Alemão
Publicado em: German Medical Science GMS Publishing House 2006-02-01
Colecção:GMS German Medical Science
Assuntos:
dendritic cell vaccination
telomerase
immunotherapy
renal cancer
T-cell responses
Acesso em linha:http://www.egms.de/en/gms/2006-4/000031.shtml
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