The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies

<p>Abstract</p> <p>Background</p> <p>The conserved CD4 binding site (CD4bs) on HIV-1 gp120 is a major target for vaccines. It is a priority to determine sites and structures within the CD4bs that are important for inclusion in vaccines. We studied a gp120 pocket penetra...

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Main Authors: Dueñas-Decamp Maria J, O'Connell Olivia J, Corti Davide, Zolla-Pazner Susan, Clapham Paul R
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-01-01
Serier:Retrovirology
Fag:
HIV
envelope
gp120
CD4 binding site
neutralization
Online adgang:http://www.retrovirology.com/content/9/1/9
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