Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and Successful Tolerance Induction Strategies in Pig-To-Primate Transplantation

Organ transplantation is the most effective treatment for end stage organ failure, but there are not enough organs to meet burgeoning demand. One potential solution to this organ shortage is xenotransplantation using pig tissues. Decades of progress in xenotransplantation, accelerated by the develop...

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Autori principali: Daniel L. Eisenson, Yu Hisadome, Kazuhiko Yamada
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-05-01
Serie:Frontiers in Immunology
Soggetti:
xenotransplantation
thymic transplantation
Mixed hematopoietic cell chimerism
thymokidney
vascularized thymic lobe transplantation
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2022.899657/full
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