Á lódáil...
N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.
The gene dnph1 (or rcl) encodes a hydrolase that cleaves the 2'-deoxyribonucleoside 5'-monophosphate (dNMP) N-glycosidic bond to yield a free nucleobase and 2-deoxyribose 5-phosphate. Recently, the crystal structure of rat DNPH1, a potential target for anti-cancer therapies, suggested that...
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| Main Authors: | , , , , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Public Library of Science (PLoS)
2013-01-01
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| Sraith: | PLoS ONE |
| Rochtain Ar Líne: | http://europepmc.org/articles/PMC3834327?pdf=render |
| Clibeanna: |
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