Laddar...
N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.
The gene dnph1 (or rcl) encodes a hydrolase that cleaves the 2'-deoxyribonucleoside 5'-monophosphate (dNMP) N-glycosidic bond to yield a free nucleobase and 2-deoxyribose 5-phosphate. Recently, the crystal structure of rat DNPH1, a potential target for anti-cancer therapies, suggested that...
Sparad:
| Huvudupphovsmän: | , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science (PLoS)
2013-01-01
|
| Serie: | PLoS ONE |
| Länkar: | http://europepmc.org/articles/PMC3834327?pdf=render |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|