PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration

Lipid nanoparticles (LNPs) exhibit high potential as carriers of messenger RNA (mRNA). However, the arduous preparation process of mRNA-loaded LNPs remains a huge obstacle for their widespread clinical application. Herein, we tackled this issue by mRNA PEGylation through hybridization with polyethyl...

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Autores principales: Shota Kurimoto, Naoto Yoshinaga, Kazunori Igarashi, Yu Matsumoto, Horacio Cabral, Satoshi Uchida
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2019-04-01
Colección:Molecules
Materias:
mRNA delivery
mRNA-engineering
lipid nanoparticles
polyethylene glycol
hybridization
RNA oligonucleotide
steric stabilization
Acceso en línea:https://www.mdpi.com/1420-3049/24/7/1303
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