Dose Assessment of Cefquinome by Pharmacokinetic/Pharmacodynamic Modeling in Mouse Model of Staphylococcus aureus Mastitis

This work aimed to characterize the mammary gland pharmacokinetics of cefquinome after an intramammary administration and integrate pharmacokinetic/pharmacodynamic model. The pharmacokinetic profiles of cefquinome in gland tissue were measured using high performance liquid chromatograph. Therapeutic...

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Detalhes bibliográficos
Main Authors: Yang Yu, Yu-feng Zhou, Xiao Li, Mei-Ren Chen, Gui-Lin Qiao, Jian Sun, Xiaoping Liao, Ya-Hong Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-10-01
Colecção:Frontiers in Microbiology
Assuntos:
Mastitis
Monte Carlo simulation
PK/PD modeling
Dose assessment
Cefquinome
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01595/full
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