Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid CB2 receptors reverses allodynia and hyperalg...

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Main Authors: Zachary W. Reichenbach, Kelly DiMattio, Suren Rajakaruna, David Ambrose, William D. Cornwell, Ronald J. Tallarida, Thomas Rogers, Lee-Yuan Liu-Chen, Ronald F. Tuma, Sara Jane Ward
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Assuntos:
morphine
CB2 receptor agonist
antinociception
antinociceptive tolerance
inflammation
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fphar.2022.803331/full
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