Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor

Abstract Spinal cord injury (SCI) will result in the significant elevation of thrombin production at lesion site via either breakage of blood-spinal cord barrier or upregulated expression within nerve cells. Thrombin-induced activation of the protease activated receptors (PARs) evokes various pathol...

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Bibliographic Details
Main Authors: Xiaojun Chen, Han Zhang, Huifei Hao, Xingyuan Zhang, Honghua Song, Bingqiang He, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu, Yongjun Wang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2022-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00997-4
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