Genetically Modified Mouse Models of Congenital Diaphragmatic Hernia: Opportunities and Limitations for Studying Altered Lung Development

Congenital diaphragmatic hernia (CDH) is a relatively common and life-threatening birth defect, characterized by an abnormal opening in the primordial diaphragm that interferes with normal lung development. As a result, CDH is accompanied by immature and hypoplastic lungs, being the leading cause of...

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Detalhes bibliográficos
Main Authors: Florian Friedmacher, Udo Rolle, Prem Puri
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Pediatrics
Assuntos:
congenital diaphragmatic hernia
diaphragm development
lung development
pulmonary hypoplasia
pulmonary hypertension
genetic model
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fped.2022.867307/full
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