Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation

Abstract Background The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of tissue-specific DNA methylation (DNAm) variation in human populations. To date, characterizations of inter-individual DNAm variability and DNAm concordance...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Sumaiya A. Islam, Sarah J. Goodman, Julia L. MacIsaac, Jelena Obradović, Ronald G. Barr, W. Thomas Boyce, Michael S. Kobor
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BMC 2019-01-01
श्रृंखला:Epigenetics & Chromatin
विषय:
DNA methylation
Genetic variation
Surrogate tissues
Peripheral blood leukocytes
Buccal epithelial cells
Illumina 450K array
ऑनलाइन पहुंच:http://link.springer.com/article/10.1186/s13072-018-0245-6
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