Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation

Abstract Background The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of tissue-specific DNA methylation (DNAm) variation in human populations. To date, characterizations of inter-individual DNAm variability and DNAm concordance...

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Hlavní autoři: Sumaiya A. Islam, Sarah J. Goodman, Julia L. MacIsaac, Jelena Obradović, Ronald G. Barr, W. Thomas Boyce, Michael S. Kobor
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2019-01-01
Edice:Epigenetics & Chromatin
Témata:
DNA methylation
Genetic variation
Surrogate tissues
Peripheral blood leukocytes
Buccal epithelial cells
Illumina 450K array
On-line přístup:http://link.springer.com/article/10.1186/s13072-018-0245-6
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