Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation

Abstract Background The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of tissue-specific DNA methylation (DNAm) variation in human populations. To date, characterizations of inter-individual DNAm variability and DNAm concordance...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sumaiya A. Islam, Sarah J. Goodman, Julia L. MacIsaac, Jelena Obradović, Ronald G. Barr, W. Thomas Boyce, Michael S. Kobor
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2019-01-01
Cyfres:Epigenetics & Chromatin
Pynciau:
DNA methylation
Genetic variation
Surrogate tissues
Peripheral blood leukocytes
Buccal epithelial cells
Illumina 450K array
Mynediad Ar-lein:http://link.springer.com/article/10.1186/s13072-018-0245-6
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg