Oligomerization and Ca2+/calmodulin control binding of the ER Ca2+-sensors STIM1 and STIM2 to plasma membrane lipids

Ca2+ (calcium) homoeostasis and signalling rely on physical contacts between Ca2+ sensors in the ER (endoplasmic reticulum) and Ca2+ channels in the PM (plasma membrane). STIM1 (stromal interaction molecule 1) and STIM2 Ca2+ sensors oligomerize upon Ca2+ depletion in the ER lumen, contact phosphoino...

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Autors principals: Rajesh Bhardwaj, Hans‑Michael Müller, Walter Nickel, Matthias Seedorf
Format: Artigo
Idioma:Inglês
Publicat: Portland Press, Biochemical Society 2013-10-01
Col·lecció:Bioscience Reports
Matèries:
calmodulin (CaM)
ER–PM contact site
phosphoinositides
K-rich domain
STIM2
store-operated calcium entry (SOCE)
Accés en línia:http://www.bioscirep.org/bsr/033/e077/bsr033e077.htm
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