The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma

Interleukin-1 (IL-1) plays a key role in carcinogenesis and several IL-1-targeted therapeutics are under investigation for the treatment of pancreatic ductal adenocarcinoma (PDAC). We sought to broaden our understanding of how the family of IL-1 ligands and receptors impact the tumor immune landscap...

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Main Authors: Kelly M. Herremans, Dominique D. Szymkiewicz, Andrea N. Riner, Riley P. Bohan, Gerik W. Tushoski, Aaron M. Davidson, XiangYang Lou, Man Chong Leong, Bayli DiVita Dean, Michael Gerber, Patrick W. Underwood, Song Han, Steven J. Hughes
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2022-06-01
Series:Neoplasia: An International Journal for Oncology Research
Assuntos:
Pancreas cancer
Bioinformatics
Immunology
Immune checkpoint
Survival
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S1476558622000185
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