Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract

Abstract Zika virus (ZIKV) can cause devastating effects in the unborn fetus of pregnant women. To develop a candidate vaccine that can protect human fetuses, we generated a panel of live measles vaccine (MV) vectors expressing ZIKV-E and -NS1. Our MV-based ZIKV-E vaccine, MV-E2, protected mice from...

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Autores principales: Drishya Kurup, Christoph Wirblich, Rachael Lambert, Leila Zabihi Diba, Benjamin E. Leiby, Matthias J. Schnell
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2022-04-01
Colección:npj Vaccines
Acceso en línea:https://doi.org/10.1038/s41541-022-00464-2
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