The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

ATP-binding cassette (ABC) transporters, such as breast cancer resistance protein (BCRP), are key players in resistance to multiple anti-cancer drugs, leading to cancer treatment failure and cancer-related death. Currently, there are no clinically approved drugs for reversal of cancer drug resistanc...

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Detalhes bibliográficos
Main Authors: Sophie E. B. Ambjørner, Michael Wiese, Sebastian Christoph Köhler, Joen Svindt, Xamuel Loft Lund, Michael Gajhede, Lasse Saaby, Birger Brodin, Steffen Rump, Henning Weigt, Nils Brünner, Jan Stenvang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-03-01
Colecção:Cells
Assuntos:
multidrug resistance in cancer
drug efflux pumps
atp-binding cassette transporter
breast cancer resistance protein (bcrp), abcg2
pyrazolo-pyrimidine derivative
sco-201
Acesso em linha:https://www.mdpi.com/2073-4409/9/3/613
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