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Design of phase II non-inferiority trials

With the development of inexpensive treatment regimens and less invasive surgical procedures, we are confronted with non-inferiority study objectives. A non-inferiority phase III trial requires a roughly four times larger sample size than that of a similar standard superiority trial. Because of the...

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Détails bibliographiques
Auteur principal: Sin-Ho Jung
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017-09-01
Collection:Contemporary Clinical Trials Communications
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S245186541630134X
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