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Design of phase II non-inferiority trials
With the development of inexpensive treatment regimens and less invasive surgical procedures, we are confronted with non-inferiority study objectives. A non-inferiority phase III trial requires a roughly four times larger sample size than that of a similar standard superiority trial. Because of the...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2017-09-01
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| Schriftenreihe: | Contemporary Clinical Trials Communications |
| Online Zugang: | http://www.sciencedirect.com/science/article/pii/S245186541630134X |
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