Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disorder mainly affecting old population. In this study, two Tau overexpressing cell lines (SH-SY5Y/Tau and HEK293/Tau), N2a/SweAPP cell line, and 3× Transgene (APPswe/PS1M146V/TauP301L) mouse primary nerve cell lines were used as AD models to stu...

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Detalhes bibliográficos
Main Authors: Liang Gu, Nan Cai, Meiting Li, Decheng Bi, Lijun Yao, Weishan Fang, Yan Wu, Zhangli Hu, Qiong Liu, Zhijian Lin, Jun Lu, Xu Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Nutrition
Assuntos:
Alzheimer's disease
macelignan
AMPK pathway
autophagy
PERK/eIF2α pathway
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnut.2022.892558/full
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