Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

The trajectories of hematopoietic stem cells (HSCs) during lineage commitment are complex. Here, the authors use single cell RNA-sequencing and xenotransplantation to uncover CD34 + EPCR + (CD38/CD45RA)- HSCs, which high repopulating and self-renewal properties.

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Hlavní autoři: Fernando Anjos-Afonso, Florian Buettner, Syed A. Mian, Hefin Rhys, Jimena Perez-Lloret, Manuel Garcia-Albornoz, Namrata Rastogi, Linda Ariza-McNaughton, Dominique Bonnet
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2022-04-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-022-29675-w
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