Characterization of WWOX expression and function in canine mast cell tumors and malignant mast cell lines

Abstract Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA damage repair, and genomic stability...

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Main Authors: Rebecca Makii, Hanna Cook, Darian Louke, Justin Breitbach, Ryan Jennings, Christopher Premanandan, Eric M. Green, Joelle M. Fenger
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-10-01
Colecção:BMC Veterinary Research
Assuntos:
Canine mast cell tumors
WWOX
DNA damage response
Acesso em linha:http://link.springer.com/article/10.1186/s12917-020-02638-3
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