Construction of a novel quinoxaline as a new class of Nrf2 activator

Abstract Background The transcription factor Nuclear factor erythroid-2-related factor 2 (NRF2) and its principal repressive regulator, Kelch-like ECH-associated protein 1 (KEAP1), are perilous in the regulation of inflammation, as well as maintenance of homeostasis. Thus, NRF2 activation is involve...

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Main Authors: Murugesh Kandasamy, Kit-Kay Mak, Thangaraj Devadoss, Punniyakoti Veeraveedu Thanikachalam, Raghavendra Sakirolla, Hira Choudhury, Mallikarjuna Rao Pichika
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-09-01
Colecção:BMC Chemistry
Assuntos:
N′-nicotinoylquinoxaline-2-carbohydrazide
NRF2
KEAP1
Anti-inflammatory
Metabolic stability
Molecular docking
Acesso em linha:http://link.springer.com/article/10.1186/s13065-019-0633-4
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