Biological and structural characterization of a host-adapting amino acid in influenza virus.

Two amino acids (lysine at position 627 or asparagine at position 701) in the polymerase subunit PB2 protein are considered critical for the adaptation of avian influenza A viruses to mammals. However, the recently emerged pandemic H1N1 viruses lack these amino acids. Here, we report that a basic am...

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Main Authors: Shinya Yamada, Masato Hatta, Bart L Staker, Shinji Watanabe, Masaki Imai, Kyoko Shinya, Yuko Sakai-Tagawa, Mutsumi Ito, Makoto Ozawa, Tokiko Watanabe, Saori Sakabe, Chengjun Li, Jin Hyun Kim, Peter J Myler, Isabelle Phan, Amy Raymond, Eric Smith, Robin Stacy, Chairul A Nidom, Simon M Lank, Roger W Wiseman, Benjamin N Bimber, David H O'Connor, Gabriele Neumann, Lance J Stewart, Yoshihiro Kawaoka
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Pathogens
Acceso en liña:http://europepmc.org/articles/PMC2916879?pdf=render
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