Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial

Abstract Background Chronic rhinosinusitis (CRS) is a common source of ill health; 11% of UK adults reported CRS symptoms in a worldwide population study. Guidelines are conflicting regarding whether antibiotics should be included in primary medical management, reflecting the lack of evidence in sys...

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Autori principali: Carl Philpott, Steffi le Conte, David Beard, Jonathan Cook, William Sones, Steve Morris, Caroline S. Clarke, Mike Thomas, Paul Little, Jane Vennik, Valerie Lund, Helen Blackshaw, Anne Schilder, Stephen Durham, Spiros Denaxas, James Carpenter, James Boardman, Claire Hopkins, On behalf of the MACRO programme team
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-04-01
Serie:Trials
Soggetti:
chronic rhinosinusitis
endoscopic sinus surgery
clarithromycin
randomised controlled trial
Accesso online:http://link.springer.com/article/10.1186/s13063-019-3314-7
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