Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines

Abstract Background All-trans retinoic acid (ATRA) is currently being used to treat hematological malignancies, given the ability to inhibit cell proliferation. This effect seems to be related to epigenetic changes of the TERT (Telomerase Reverse Transcriptase) promoter. When hypomethylated, ATRA-in...

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Main Authors: Lorena Losi, Angela Lauriola, Erica Tazzioli, Gaia Gozzi, Letizia Scurani, Domenico D’Arca, Jean Benhattar
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-07-01
Series:Journal of Ovarian Research
Assuntos:
Ovarian cancer, serous ovarian carcinoma
ATRA
TERT
Telomerase
DNA methylation
Cell lines
Acceso en liña:http://link.springer.com/article/10.1186/s13048-019-0536-y
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