Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine

Coxiella burnetii, the causative agent of Q fever, is a Gram-negative intracellular bacterium transmitted via aerosol. Regulatory approval of the Australian whole-cell vaccine Q-VAX® in the US and Europe is hindered by reactogenicity in previously exposed individuals. The aim of this study was to id...

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Detalhes bibliográficos
Main Authors: Anja Scholzen, Guilhem Richard, Leonard Moise, Laurie A. Baeten, Patrick M. Reeves, William D. Martin, Timothy A. Brauns, Christine M. Boyle, Susan Raju Paul, Richard Bucala, Richard A. Bowen, Anja Garritsen, Anne S. De Groot, Ann E. Sluder, Mark C. Poznansky
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-02-01
Colecção:Frontiers in Immunology
Assuntos:
Coxiella burnetii
Q fever
multi-epitope vaccine
immunoinformatics
IFNγ
T cell
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.00207/full
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