Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup<sup>®</sup> Dietary Supplement: Role of Green Tea Catechins

Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have shown the safety and efficacy to improve cognitive phenotypes using commercial...

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Main Authors: Yuchen Gu, Gautier Moroy, Jean-Louis Paul, Anne-Sophie Rebillat, Mara Dierssen, Rafael de la Torre, Cécile Cieuta-Walti, Julien Dairou, Nathalie Janel
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Assuntos:
dyrk1a
docking
egcg
ecg
rtk pathway
bdnf
Acceso en liña:https://www.mdpi.com/1422-0067/21/4/1404
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