Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma

Neoantigens represent promising targets for personalized cancer vaccine strategies. However, the feasibility of this approach in lower mutational burden tumors like glioblastoma (GBM) remains unknown. We have previously reported the use of an immunogenomics pipeline to identify candidate neoantigens...

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Detalhes bibliográficos
Main Authors: Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Gavin P. Dunn
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2019-04-01
Colecção:OncoImmunology
Assuntos:
neoantigen
immunogenomics
glioblastoma
personalized vaccine
clonal evolution
Acesso em linha:http://dx.doi.org/10.1080/2162402X.2018.1561106
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