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DYT1 knock-in mice are not sensitized against mitochondrial complex-II inhibition.

DYT1 is caused by a partly penetrant dominant mutation in TOR1A that leads to a glutamic acid deletion (ΔE) in torsinA. Identifying environmental factors that modulate disease pathogenesis and penetrance could help design therapeutic strategies for dystonia. Several cell-based studies suggest that e...

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Autori principali: Nicole Bode, Cory Massey, Pedro Gonzalez-Alegre
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3411799?pdf=render
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