Intestinal Barrier Dysfunction in the Absence of Systemic Inflammation Fails to Exacerbate Motor Dysfunction and Brain Pathology in a Mouse Model of Parkinson's Disease

IntroductionParkinson's disease (PD) is the second most common neurodegenerative disease associated with aging. PD patients have systemic and neuroinflammation which is hypothesized to contribute to neurodegeneration. Recent studies highlight the importance of the gut-brain axis in PD pathogene...

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Hauptverfasser: Aeja Jackson, Phillip A. Engen, Christopher B. Forsyth, Maliha Shaikh, Ankur Naqib, Sherry Wilber, Dulce M. Frausto, Shohreh Raeisi, Stefan J. Green, Brinda Desai Bradaric, Amanda L. Persons, Robin M. Voigt, Ali Keshavarzian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-05-01
Schriftenreihe:Frontiers in Neurology
Schlagworte:
Parkinson's disease
intestinal hyperpermeability
dextran sodium sulfate (DSS)
microbiome
gut-brain axis
Online Zugang:https://www.frontiersin.org/articles/10.3389/fneur.2022.882628/full
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