The protective role of microRNA-200c in Alzheimer’s disease pathologies is induced by beta Amyloid-triggered Endoplasmic Reticulum Stress

MicroRNAs are small non-coding RNAs that repress the expression of their target proteins. The roles of microRNAs in the development of Alzheimer’s disease (AD) are not clear. In this study we show that miR-200c represses the expression of PTEN protein. PTEN downregulation by miR-200c supports the su...

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Detalhes bibliográficos
Main Authors: Qi Wu, Xiaoyang Ye, Yi Xiong, Haili Zhu, Jianting Miao, Wei Zhang, Jun Wan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-12-01
Colecção:Frontiers in Molecular Neuroscience
Assuntos:
microRNA
Pten
Alzheimer’s disease (AD)
MiR-200c
Beta amyloid peptide
Endoplasmic reticulum stress (ER stress)
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00140/full
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