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Low dose of sodium-glucose transporter 2 inhibitor ipragliflozin attenuated renal dysfunction and interstitial fibrosis in adenine-induced chronic kidney disease in mice without diabetes

Background: Sodium–glucose co-transporter 2 (SGLT2) inhibitor, a new class of glucose lowering agents, has been shown to be reno-protective in diabetes. Objective: We aimed to explore whether SGLT2 inhibitor ipragliflozin has a direct reno-protective effect on non-diabetic chronic kidney disease (CK...

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Main Authors: Mayumi Yamato, Nao Kato, Ai Kakino, Ken-ichi Yamada, Toyoshi Inoguchi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-09-01
Colecção:Metabolism Open
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Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589936820300293
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