GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome

Summary: Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal disorders like irritable bowel syndrome (IBS), although its molecular underpinnings are poorly characterized. We studied stool frequency (defined by the number of bowel movements per day, based on que...

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Главные авторы: Ferdinando Bonfiglio, Xingrong Liu, Christopher Smillie, Anita Pandit, Alexander Kurilshikov, Rodrigo Bacigalupe, Tenghao Zheng, Hieu Nim, Koldo Garcia-Etxebarria, Luis Bujanda, Anna Andreasson, Lars Agreus, Susanna Walter, Gonçalo Abecasis, Chris Eijsbouts, Luke Jostins, Miles Parkes, David A. Hughes, Nicholas Timpson, Jeroen Raes, Andre Franke, Nicholas A. Kennedy, Aviv Regev, Alexandra Zhernakova, Magnus Simren, Michael Camilleri, Mauro D’Amato
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2021-12-01
Серии:Cell Genomics
Предметы:
gut motility
GWAS
SNP
irritable bowel syndrome
polygenic scores
genetics
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2666979X21000859
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