Coumarins and P450s, Studies Reported to-Date

Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species. In addition to their role in detoxification, they play important roles in the biosyn...

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Bibliographic Details
Main Authors: Maryam Foroozesh, Jayalakshmi Sridhar, Navneet Goyal, Jiawang Liu
Format: Artigo
Language:Inglês
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
cytochrome P450
coumarins
docking
quantitative structure-activity relationship (QSAR)
hologram quantitative structure-activity relationship (HQSAR)
comparative molecular field analysis (CoMFA)
comparative molecular similarity index analysis (CoMSIA)
molecular modeling
active site
competitive inhibition
time-dependent inhibition
Online Access:https://www.mdpi.com/1420-3049/24/8/1620
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