Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease

Pathophysiology of diabetic kidney disease (DKD) is incompletely understood. We aim to elucidate metabolic abnormalities associated with DKD in type 2 diabetes mellitus (T2DM) by targeted plasma metabolomics. Methods: A total of 126 T2DM participants with early DKD (urinary albumin-to-creatinine rat...

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Main Authors: Jian-Jun Liu, Sujoy Ghosh, Jean-Paul Kovalik, Jianhong Ching, Hyung Won Choi, Subramaniam Tavintharan, Choon Nam Ong, Chee Fang Sum, Scott A. Summers, E. Shyong Tai, Su Chi Lim
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-05-01
Serier:Kidney International Reports
Fag:
diabetic kidney disease
energetic fuel substrate
metabolomics
pathophysiology
type 2 diabetes mellitus
Online adgang:http://www.sciencedirect.com/science/article/pii/S2468024916301814
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